TTK Kinase Assay Service - Reaction Biology

Activity-based TTK kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

TTK

Enzyme

Human TTK

HGNC

TTK

Synonym

ESK, MPS1L1, MPS1, PYT

Substrates

MBP (Myelin Basic Protein), 20 µM
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

P33981 (http://www.uniprot.org/uniprot/P33981)

Screening Location

Malvern, USA

Reference compound IC50 for TTK