TYK1/LTK Kinase Assay Service

Activity-based TYK1/LTK kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

TYK1

Enzyme

Human TYK1

HGNC

LTK

Synonym

TYK1

Substrates

Peptide substrate, [EAIYAAPFAKKK], 20 µM
ATP, 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

P29376 (http://www.uniprot.org/uniprot/P29376)

Screening Location

Malvern, USA

Reference compound IC50 for TYK1/LTK