TYK2 Kinase Assay Service - Reaction Biology

Activity-based TYK2 kinase assay for compound screening and profiling via radiometric HotSpot^TM kinase assay.

Target Overview

CAT#

TYK2

Enzyme

TYK2

HGNC

TYK2

Synonym

JTK1

Substrates

Peptide substrate, [KKSRGDYMTMQIG], 20 µM
ATP 10 µM

Assay Properties

Reaction

Substrate + [γ-³³P]-ATP = ³³P-Substrate + ADP

Readout

Enzymatic activity

Reference Compound IC50s

Scientific Information

P29597 (http://www.uniprot.org/uniprot/P29597)

Screening Location

Malvern, USA

Reference compound IC50 for TYK2