Safety & Toxicology
Safety & Toxicology

Safety & Toxicology Services

Our Solutions for Safety Pharmacology

Our portfolio of safety & toxicology screening services spans in vitro targets (including biochemical, functional cell-based, CYP, cardiac safety, PDE, and kinase diversity targets) under our In Vitro Evaluation of Safety and Toxicity (InVEST) brand, in vivo safety models, and GLP toxicology assays. Across our safety services, we offer both preset panels and customizable targets.

In Vitro Safety Screening

This convenient service screens your compounds against over 100 targets known to be involved in human toxicity to aid with compound selection and early safety assessments. Available assay formats include enzymatic, biochemical binding, cell-based functional, and radioligand binding assays.

Cardiac Safety Assessment

The cardiac safety assessment assays are available for preclinical evaluation of the safety of compounds to identify toxic drugs potentially inducing fatal cardiac tachyarrhythmia.

Cytochrome P450 Assays

Reaction Biology provides compound profiling against the 14 most important CYP isoforms to provide early guidance on a compound’s toxicity.

Regulatory Toxicology
Maximum-Tolerated Dose

The identification of the Maximum-Tolerated Dose (MTD) is one of the first steps when taking a drug candidate from in vitro to in vivo phase of drug discovery. The MTD is the dose at which certain toxicity specified in advance occurs only in a predetermined tolerable proportion of the animals.