Overview of In Vivo Pharmacology Services

Reaction Biology offers a comprehensive portfolio of mouse tumor models for in vivo testing of new anti-cancer drugs. Our integrated drug testing platform includes services for all steps of the drug discovery process, supporting the development of your preclinical candidate pipeline.

The premises of our CRO feature a state-of-the-art animal facility is located in Germany. All of our services for in vivo testing are conducted under GV-SOLAS and ISO9001 in regard to standards of animal welfare and code of practice.

Our preclinical oncology service portfolio is supplemented by options to assess drug tolerability, PK, and PD in mice.

Human xenograft tumor models are the most frequently used in vivo models for the evaluation of the therapeutic effects of novel anti-cancer drug candidates, including subcutaneous, subQperior, orthotopic, and metastasis models.

The In Vivo Hollow Fiber Model is an efficient and economic screening approach which is used for two purposes: (i) Select the compound with the best in vivo activity ("compound screening"), or (ii) identify a suitable tumor cell line for in vivo efficacy studies ("tumor model screening")

Genetically engineered tumor models are well suited for the investigation of a single driver of tumor growth such as an overexpressed or constitutively expressed kinase.