Cell Line-Derived Syngeneic Tumor Models

Syngeneic tumor models are used for efficacy testing of immune-modulatory drugs and the investigation of effects of conventional anti-cancer drugs on the immune system.

Our panel of cell line-derived syngeneic tumor models comprises subcutaneous, subQperior, orthotopic, and metastasis models. SubQperior tumor models that are based on cell implantation into the mammary fat pad of mice feature reduced tumor ulceration and yield more homogeneous tumor growth and ultimately outstanding statistical evaluation of drug efficacy testing. In addition to standard syngeneic models, Reaction Biology offers proprietary syngeneic test systems, named Mouse-derived Isograft Models (MDI).

• Science-driven study setup with a focus on reproducible and meaningful results
• Custom-tailored reports written by PhD level medical writers will be provided for every study
• Regular panel screening of 6 tumor models for economic efficacy evaluation of new IO drug candidates
• Comprehensive flow cytometry analysis capacity with 17 marker staining panel