Syngeneic Mouse Models

Syngeneic tumor models are used for efficacy testing of immuno-oncologic drugs and the investigation of the effects of conventional anti-cancer drugs on the immune system.

Our panel of cell line-derived syngeneic tumor models (CDX) comprises subcutaneous, subQperior, orthotopic, and metastasis models. Our innovative subQperior^TM tumor models are based on cell implantation into the mammary fat pad of mice and feature reduced tumor ulceration and yield more homogeneous tumor growth and ultimately outstanding statistical evaluation of drug efficacy testing. In addition to standard syngeneic cancer models, Reaction Biology also offers proprietary tissue-based immuno-oncology models, named Mouse-derived Isograft Models (MDI).

• Science-driven study setup with a focus on reproducible and meaningful results
• Custom-tailored reports written by PhD level medical writers will be provided for every in vivo study
• Regular syngenic panel screening of 6 syngeneic tumor models for economic efficacy evaluation of new immuno-oncology drug candidates
• Comprehensive flow cytometry analysis capacity with 17 marker staining panel