Kinesin ATPase Assay Services
Kinesin superfamily proteins (KIFs) are a large family of molecular motor proteins, that share a highly conserved motor domain. Molecular motors convert chemical energy into mechanical work to achieve active cellular processes. Kinesins move along microtubule filaments utilizing energy from ATP hydrolysis and play important role in cell division and transport of vesicles and organelles within cells.
Altered expressions of several kinesins are shown in various cancers, fueling the aggressive nature of cancers leading to genomic instability. Eg5/KIF11 overexpression is shown in various cancers including hepatic carcinoma, lung, prostate, colorectal, gastric, and pancreatic cancers. Small molecule inhibitors of KIF11/Eg5 and CENP-E/ KIF10 are shown to result in mitotic arrest leading to apoptosis in tumor cell lines. Recently, an inhibitor targeting Kinesin 8 family member KIF18A, has entered clinical trial for treatment of solid tumors with high chromosomal instability several other kinesins such MCAK, MKLP2/KIF20A, KIF22 and MKLP1/KIF23 are shown to be aberrantly regulated in several cancers attracted interest in anti-cancer therapeutic discovery.
