Reaction Biology supports clients with pharmacokinetic (PK) and pharmacodynamic (PD) studies to understand the interaction of the drug and body. In the early preclinical research phase of a new drug, PK studies provide data necessary for determining a dosing schedule and route of administration for in vivo efficacy testing. PD studies give an insight into whether the drug actually does act on its target in the mouse body.
Pharmacokinetics (PK) is a fundamental aspect of drug discovery for the characterization of drug candidates in hit-to-lead and lead optimization programs in regards to adsorption, distribution, metabolism, and excretion after administration to mice.
Setups:
Routes of administration:
Samples:
Bioanalysis of the samples is performed by our collaborator Pharmacelsus GmbH
Sample Preparation:
Substance Identification:
Deliverable:
Options:
We can conduct pharmacokinetic (PK) studies on animal models:
Please contact us for additional information.
Pharmacodynamic (PD) is the area in pharmacology to determine how the drug acts on the body. At the endpoint of a mouse study, organs or tumor tissue is isolated and subjected for testing of biomarkers, functional readouts and efficacy on the target molecule.
Tumor tissue or other tissue can be subject to a variety of readouts:
