Human Xenograft Models

Human xenograft tumor models are the most frequently used test systems for the evaluation of in vivo efficacy of novel anti-cancer drug candidates. Cell line-derived xenograft tumor models (CDX) are well established with a long history of tumor model characterization and reference drug efficacy data.

Xenograft models are based on the implantation of human tumor cells into immunocompromised mice to avoid graft versus host reaction of the mouse against the human tumor tissue. Reaction Biology's in vivo tumor models are derived from a variety of origins such as breast, colon, lung, skin, blood. In vivo efficacy studies can be performed on subcutaneous, orthotopic, and metastasis models.

  • Our CRO offers in vivo efficacy studies with well-validated tumor models
  • Custom-tailored reports written by Ph.D. level medical writers will be provided for every in vivo study
  • Science-driven study setup with a focus on reproducible and meaningful results

List of Human Xenograft Tumor Models

Cell line Tissue Orgin Available Tumor Models
A2058 Skin
A375 Skin
A549 Lung
AsPC1 Pancreas
BxPC-3 Pancreas
C8161 Skin subcutaneous
Calu-3 Lung subcutaneous
Calu-6 Lung
Colo-205 Colon
COLO-320DM Colon subcutaneous
H460 Lung
HCC-1569 Breast orthotopic
HCT-116 Colon
HeLa Cervix
HG3 Blood /Leukemia subcutaneous
HL-60 Blood /Leukemia
Hs746T Stomach
HT-144 Skin subcutaneous
HT29 Colon
HuTu80 Duodenum
JIMT1 Breast
KARPAS 299 Blood /Leukemia
LN-229 Brain
LS 174T Colon
MCF7 Breast
MDA-MB-231 Breast
MiAPaCa2 Pancreas
MKN-1 Stomach
MKN-45 Stomach
MOLM-13 Blood /Leukemia
Molt-4 Blood /Leukemia subcutaneous
MV4-11 Blood /Leukemia
NCI-H1437 Lung subcutaneous
NCI-H292 Lung subcutaneous
NCI-H441 Lung subcutaneous
PC-3 Prostate
SJSA-1 Bone
SKOV-3 Ovary
SW620 Colon
THP-1 Blood /Leukemia
U-118 MG Brain
U-87 MG Brain

Explore the Options for Tumor Placement