Overview of Target-Specific Assay Services
Reaction Biology offers compound screening assays for more than 1000 targets to support the discovery of new drugs. Most of our assays are high-throughput compatible and can be customized to your specific requirements.
Reaction Biology offers the largest portfolio of kinase assays in the industry. We are dedicated to provide end-to-end service for kinase drug discovery covering all steps of the preclinical drug discovery process.
- Kinase Assay Services
- Kinase Panel Screening
- Cellular Kinase Assays
- EGFR Drug Discovery
- Kinase SubstrateFinder
- KinaseFinder
- Customized Kinase Drug Discovery
- In Vivo Kinase Activity Models
- Recombinant Kinase-related Products
Epigenetic enzymes control the mechanics of genetic expression, acting as “on” and “off” switches for the human genome. Malfunctions of these enzymes are implicated in many immunological and neurodegenerative conditions as well as cancer. We are dedicated to providing end-to-end service for epigenetic drug discovery covering all steps of the preclinical drug discovery process.
- Cell-based Epigenetic Assays
- Reader Domain Assays
- Methyltransferase Assays
- Demethylase Assays
- Histone Acetyltransferase Assays (HAT)
- Histone Deacetylase (HDAC) & Sirtuin Assays
- Isocitrate Dehydrogenase Assays (IDH)
- Customized Epigenetic Drug Discovery
A suite of assay formats is available for drug discovery targeting the KRAS pathway. Biochemical and biophysical methods allow the investigation of different KRAS regulators.
The approach of Targeted Protein Degradation does not just inhibit a target, it erases the target. Reaction Biology offers a suite of assays to support the creation of new drugs targeting proteins for their degradation in tumor cells.
Compound screening against Poly (ADP-ribose) polymerase (PARP) enzymes is performed with gold standard radiometric activity assays.
The activity of phosphatases is quantified with a fluorescence-based approach for anti-phosphatase compound profiling.
Our large panel of protease assays allows targeted drug discovery of protease inhibitors as well as selectivity screening with our protease panel. All assays are fluorescence-based and quantify protease activity.
Reaction Biology offers assays for the investigation of test molecules targeting the apoptosis pathway. The assay technology measures the binding of the apoptotic protein such as BCL2 to a substrate peptide such as BAK.
- Isocitrate Dehydrogenase Assays (IDH)
- Carboxylase Assays
- NAD(P)H Dehydrogenase (NQO)
- Nucleotide Metabolism Pathway Assays
To support the discovery of new drugs against phosphodiesterase enzymes Reaction Biology offers activity assays for compound screening.
Reaction Biology offers a suite of cell-based assays to support the discovery of new drugs to modulate nuclear receptors.
Reaction Biology can assist you with the production of proteins and assays for a variety of target classes such as kinases, epigenetics, PARPs, DUB, HSP, protease, phosphatase, and many more.