by John Hewitt | May 12, 2021 | Blog
Advantages of using cell-based kinase assays The failure of many compounds proven to be active in a biochemical assay upon later testing in cell-based assays is a disappointing and costly fact of life. The figure above shows the IC50 values for inhibitors of PLK1...
by John Hewitt | May 12, 2021 | Blog
Repurposing of kinase inhibitors to target SARS-CoV-2 In the face of proliferating viral variants which up the ante for vetting precise drug interactions, already approved small molecule kinase inhibitors showing efficacy against SARS-CoV-2 symptoms and sequelae are...
by John Hewitt | Feb 1, 2021 | Blog
Association and dissociation constants give insight into an inhibitor’s potential efficacy and safety The determination of the equilibrium dissociation constant, KD, for binding of a potential drug to a target is the first step for the identification of hits....
